Search Result

Search Results for " p 15 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T24584	P505-15 Acetate	PRT 062607 Acetate,P505 15 Acetate,PRT-062607 Acetate,PRT062607 Acetate,P50515 Acetate	Tyrosinase
	P505-15 Acetate is a selective inhibitor of spleen tyrosine kinase that acts by suppressing leukocyte immune function and inflammation and leading to a reduction in arthritis score and attenuated histological damage.		Tyrosinase
T10142L	p-Ethynylphenylalanine hydrochloride	4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base)	Hydroxylase
	p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selectively and reversibly the b...		Hydroxylase
T79261	P-gp inhibitor 15
	P-gp Inhibitor 15 (compound 7a), a nonsubstrate inhibitor of P-glycoprotein (Pgp), inhibits Pgp-ATPase activity and interferes with Pgp-mediated Rhodamine123 efflux. Additionally, this compound enhances the inhibitory ef...
T60619	CDK9-IN-15		CDK
	CDK9-IN-15 is a potent small molecule CDK9 inhibitor, which can block the phosphorylation of positive transcription elongation factor b (P-TEFb) on the C-terminal region of RNA Poly-II by degradation and inhibition of CD...		CDK
T62737	KRAS inhibitor-15
	KRAS inhibitor-15 (compound 3-19) is a potent inhibitor of KRAS G12C (IC50: 0.954 μM). KRAS inhibitor-15 exhibits p-ERK inhibition in MIA PaCA-2, A549 cells with IC50s of 2.03, >33.3 μM, respectively. KRAS inhibitor-15 h...
T36944	Ara-G		Nucleoside Antimetabolite/Analog
	Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine .1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporate...		Nucleoside Antimetabolite/Analog
T79353	P-gp/BCRP-IN-2
	P-gp/BCRP-IN-2 (compound 15), an oxadiazole derivative, functions as a dual inhibitor targeting both the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP (IC50: 600 nM). Additionally, it bolsters the anti-prolifera...
T10453	BACE1-IN-5		Beta Amyloid , BACE
	BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM aga...		Beta Amyloid , BACE
T69316	DA 3003-2	NSC663285
	DA 3003-2, a selectively potent Cdc25 inhibitor, exhibits antiproliferative activity and holds potential for prostate cancer research. It induces cell cycle arrest at the G2/M phase and increases the expression of P-tyr ...
T9538	3,5-Di-tert-butylbenzaldehyde		Others
	3,5-Di-tert-butylbenzaldehyde may be used in the synthesis of the following:5-p-pyridyl-15-(3,5-di-tert-butylphenyl)porphyrin via condensation reaction with 4-pyridinecarboxaldehyde and 2,2′-dipyrrylmethane.3,5-di-tert-b...		Others
T82235	HCA/Wnt/β-catenin-IN-1
	hCA/Wnt/β-catenin-IN-1 (Compd 15) serves as an inhibitor with selective affinity for hCA isoforms II, IX, and XII, exhibiting K i values of 33.6, 24.1, and 6.8 nM, respectively. Additionally, this compound attenuates P-g...
T80496	Kurtoxin		Calcium Channel
	Kurtoxin is a selective Cav3 (T-type) voltage-gated Ca2+ channel gating inhibitor, exhibiting a dissociation constant (Kd) of 15 nM for the Cav3.1 (α1G T-type) Ca2+ channel. The compound demonstrates high-affinity intera...		Calcium Channel
T35485	6-Prenylindole
	6-Prenylindole is a bacterial metabolite that has been found in Streptomyces and has antifungal and antimalarial properties.1 It is active against A. brassicicola strain TP-F0423 and F. oxysporum f. sp. tulipae TU-4-2 (1...
T71884	ß-Carboline-1-carboxylic acid
	β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when u...
T35739	Evoxanthine
	Evoxanthine is an alkaloid that has been found in O. renieri and has antimalarial and anticancer activities.1,2 It is active against P. falciparum with an IC50 value of 67.6 μg/ml.1 Evoxanthine decreases proliferation of...
T37794	Rec 15/2615 (hydrochloride)
	Rec 15/2615 is an antagonist of α1B-adrenergic receptors (α1B-ARs; Ki = 0.45 nM for the recombinant human receptor).1 It selectively inhibits α1B-ARs over α1A-, α1D-, and α1L-ARs (Kis = 7.59, 10.23, and 49 nM, respective...
T36152	14S(15R)-EET
	14S(15R)-EET is an oxylipin and a cytochrome P450 metabolite of arachidonic acid .114S(15R)-EET binds to isolated guinea pig monocytes with a Kivalue of 612.5 nM in a competitive binding assay using [3H]14(15)-EET.2It in...
T35453	β-Defensin-4 (human) (trifluoroacetate salt)
	β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at...
T38292	4-(N-Boc-amino)piperidine
	4-(N-Boc-amino)piperidine is an organic building block.1,2It has been used in the synthesis of aminopiperidine antiviral chemokine (C-C motif) receptor 5 (CCR5) antagonists and antibacterial agents. 1.Burrows, J.N., Cumm...
T35568	BODIPY-aminoacetaldehyde diethyl acetal
	BODIPY-aminoacetaldehyde diethyl acetal (BAAA-DA) is a stable precursor to BODIPY-aminoacetaldehyde, a cell-permeable fluorescent substrate for aldehyde dehydrogenase (ALDH).1,2BODIPY-aminoacetaldehyde diethyl acetal is ...
T35463	(±)14(15)-EET	(±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
	(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) i...
T36215	17R(18S)-EpETE
	17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium curren...
T37414	CAY10771
	CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively)...
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF30...
T36012	p38α inhibitor 2
	P38α Inhibitor 2, a potent and selective inhibitor of p38α MAPK, exhibits a pIC50 value of 9.6. It also demonstrates inhibition of the hERG ion channel (IC50=27 μM) and maintains promising selectivity, with <30% inhibiti...
T37761	Fura-FF (potassium salt)
	Fura-FF is a difluorinated derivative of the calcium indicator fura-2. Unlike, fura-2, fura-FF has negligible magnesium sensitivity, thus reducing interference from this cation.[1] Fura-FF also has a higher calcium disso...

Compounds

P505-15 Acetate

T24584

Synonym: PRT 062607 Acetate,P505 15 Acetate,PRT-062607 Acetate,PRT062607 Acetate,P50515 Acetate

Target: Tyrosinase

p-Ethynylphenylalanine hydrochloride

T10142L

Synonym: 4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base)

Target: Nucleoside Antimetabolite/Analog

Target: Beta Amyloid, BACE

3,5-Di-tert-butylbenzaldehyde

T9538

Synonym:

Target: Others

hCA/Wnt/β-catenin-IN-1

Target: Calcium Channel

ß-Carboline-1-carboxylic acid

Rec 15/2615 (hydrochloride)

β-Defensin-4 (human) (trifluoroacetate salt)

T35453

Synonym:

Target:

4-(N-Boc-amino)piperidine

T38292

Synonym:

Target:

BODIPY-aminoacetaldehyde diethyl acetal

Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

Fura-FF (potassium salt)

T37761

Synonym:

Target:

Cat No.	Product Name	Targets
TN2727	Jatrophane 2	P-gp , Antifection
	2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera). Ja...	P-gp , Antifection
TN2977	3-O-trans-p-Coumaroyltormentic acid	Caspase , Antifection
	3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, ...	Caspase , Antifection
T36000	3-Hydroxyterphenyllin
	3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,...

Natural Products

Jatrophane 2

TN2727

Synonym:

Target: P-gp, Antifection

3-O-trans-p-Coumaroyltormentic acid

TN2977

Synonym:

Target: Caspase, Antifection

3-Hydroxyterphenyllin

T36000

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-03395	PC4/SUB1 Protein, Human, Recombinant (His)	Human	E. coli
	SUB1 belongs to the transcriptional coactivator PC4 family. It is a general coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptio...
TMPH-01040	CBR1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	CBR1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 32.2 kDa and the accession number is P16152.
TMPJ-01323	NTAL Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Linker for Activation of T-Cells Family Member 2 (LAT2) is a single-pass type III membrane protein. LAT2 is highly expressed in the spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. LAT2 is invol...
TMPY-00803	Fibronectin Protein, Human, Recombinant (aa 607-1265, His)	Human	HEK293 Cells
	Fibronectin Protein, Human, Recombinant (aa 607-1265, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.2 kDa and the accession number is P02751-15.
TMPY-02978	ABHD14B Protein, Human, Recombinant (His)	Human	E. coli
	ABHD14B belongs to the AB hydrolase superfamily, ABHD14 family. It can be detected in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, heart, placenta, lung, liver, skeletal mu...
TMPY-05562	Fibronectin Protein, Human, Recombinant (aa 1722-1811, His)	Human	HEK293 Cells
	Fibronectin Protein, Human, Recombinant (aa 1722-1811, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 11.3 kDa and the accession number is P02751-15.
TMPK-01412	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)	Human	HEK293 Cells
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 we...
TMPK-01416	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated	Human	HEK293 Cells
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 we...